SUMMARY OBJECTIVE: Bronchiectasis is a chronic respiratory disease characterized by inflammation, irreversible dilation of the bronchi, and recurrent pulmonary infections, with a high morbidity and mortality rate, but is less studied from the point of view of its prevalence and associated factors not directly related to respiratory prognosis. As it is a disease related to the exacerbation of the inflammatory process and oxidative stress, this study searched to investigate the micronucleus frequency in patients with and without bronchiectasis treated at a specialized pulmonology service in a hospital in the extreme south of Brazil. METHODS: Patients with a confirmed tomographic diagnosis of bronchiectasis were defined as cases. Mutagenicity was evaluated by the micronucleus test in patients’ oral mucosa cells. Data collection was performed through a questionnaire containing socioeconomic, demographic, lifestyle, and health condition information. RESULTS: Of the 95 patients involved in this study, 21 (22.1%) were diagnosed with bronchiectasis aged between 12 and 89 years. There was no significant difference in the frequency of micronucleus between patients with and without bronchiectasis. There was a significant positive association between age and frequency of micronucleus among patients with bronchiectasis, but this association does not occur among patients without the disease. CONCLUSION: This is the first study to investigate data on the prevalence and clinical and epidemiological aspects of this chronic disease in Brazil, especially those related to the genotoxicity outcome.

Resumen: Objetivo: Evaluar la morbimortalidad de las bronquiectasias, su interface con el mantenimiento de las tasas de ingreso hospitalario y los resultados pronósticos insatisfactorios, y el impacto negativo en la salud pública brasileña. Métodos: Las informaciones clínicas y epidemiológicas provinieron del departamento de informática del Sistema Único de Salud de Brasil - DataSus, del cual se filtraron los datos requeridos a través de la lista de morbilidades del SUS - CID10. Se buscó información sobre la hospitalización de pacientes con bronquiectasias, como sexo, edad, tiempo y costo de la hospitalización, régimen de tratamiento y número de muertes a consecuencia de la enfermedad. Resultados: Se observó que de enero de 2008 a febrero de 2020 se hospitalizaron alrededor de 24.087 pacientes con bronquiectasias. El 65% eran adultos, con una gran porción en la fase productiva. El 84% de los pacientes buscó unidades de salud en modalidad de emergencia y el 47% acudió a los servicios públicos. El promedio brasileño de estancia hospitalaria fue estimado en 8,1 días, el costo del servicio rondaba los R$ 28 millones y se registraron 698 muertes por bronquiectasias. Conclusiones: Enfermedades como las bronquiectasias están lejos del manejo adecuado que requieren las enfermedades pulmonares crónicas. A pesar de la importante evolución diagnóstica, la etiología y el tratamiento de la enfermedad siguen siendo cuestionables.

Abstract: Objective: To evaluate the morbidity and mortality of bronchiectasis, its interface with the maintenance of hospitalization rates and unsatisfactory prognostic outcomes, as well as the negative impact on Brazilian public health. Methods: The clinical and epidemiological information came from the IT department of the Brazilian Unified Health System - DataSus, from which the required data was filtered through the SUS - CID10 list of morbidities. Information was sought, in absolute numbers, regarding the hospitalization of bronchiectasis patients, such as gender, age, time and cost of hospitalization, care regime, and the number of deaths due to the disease. Results: From the variables found, it was noted that in the period from January 2008 to February 2020, around 24,087 bronchiectasis patients were hospitalized. 65% of the total number of hospitalizations due to the disease consisted of adults, with a large portion in the productive phase (between 20 and 79 years). 84% of the patients sought health units in an emergency mode and 47% used public services at the time of hospitalization. The Brazilian average length of stay in hospital was estimated at 8.1 days and the cost of the service was around R$ 28 million in the twelve years analyzed. Besides, 698 deaths due to bronchiectasis were recorded in Brazil. Conclusions: Diseases such as bronchiectasis are far from the adequate management that chronic lung diseases require. Despite the significant diagnostic evolution, the etiology and treatment of disease is still questionable, providing unsatisfactory quality of life for bronchiectasis patients.

Resumo O objetivo deste artigo é avaliar a prevalência e os fatores associados à dor lombar nos últimos 12 meses entre adolescentes de um município do sul do estado do Piauí, Brasil. Estudo transversal com 1112 adolescentes de 13-19 anos do município de Caracol. Investigaram-se características demográficas, socioeconômicas, nutricionais, comportamentais e comorbidades. O desfecho foi a ocorrência de dor lombar (DL) nos últimos 12 meses. Foi calculada a prevalência do desfecho de acordo com as variáveis independentes. Entre os adolescentes com DL no último ano, foi calculada a proporção de indivíduos com dor lombar crônica. Para análise dos fatores associados, foi utilizada a regressão de Poisson bruta e ajustada para cálculo das razões de prevalência. A prevalência de dor lombar nos últimos 12 meses foi de 32,9%. De acordo com a análise ajustada, sexo feminino (RP = 1,75; IC95%:1,45-2,10), idade entre 18-19 anos (RP = 1,27; IC95%:1,01-1,62), maior renda (RP = 1,33; IC95%:1,06-1,67), estar trabalhando (RP 1,25 IC95%:1,02-1,53) e apresentar distúrbios psiquiátricos menores (RP 1,51 IC95%: 1,25-1,82) permaneceram associados à DL nos últimos 12 meses. Este estudo encontrou elevada prevalência de DL entre adolescentes de um município pequeno do semiárido nordestino.

Abstract The scope of this article is to assess low back pain prevalence and associated factors in the last 12 months among adolescents in a city in the south of the State of Piauí. It was a cross-sectional study which included 1,112 adolescents aged 13-19 in the city of Caracol, Piauí. Demographic, socio-economic, nutritional, behavioral and comorbidty characteristics were investigated. The outcome was the occurrence of low back pain (LBP) in the last 12 months. The outcome prevalence was calculated in accordance with independent variables. The proportion of individuals with chronic LBP was calculated among adolescents with LBP in the last 12 months. Crude and adjusted Poisson regression was used to estimate the prevalence ratio in the analysis of associated factors. The prevalence of LBP in the last 12 months was 32.9%. According to the adjusted analysis, being female (PR = 1.75; 95%CI:1.45-2.10), being aged 18-19 (PR = 1.27; 95%CI:1.01-1.62), having higher income (PR = 1.33; 95%CI:1.06-1.67), having a job (PR 1.25 95%CI:1.02-1.53) and having minor psychiatric disorders (PR 1.51 95%CI: 1.25-1.82) were associated with LBP in the last 12 months. This study found a high prevalence of LBP among adolescents in a poor city in the semiarid region of Northeast Brazil.

Resumo O objetivo deste artigo é avaliar a prevalência e os fatores associados à dor lombar nos últimos 12 meses entre adolescentes de um município do sul do estado do Piauí, Brasil. Estudo transversal com 1112 adolescentes de 13-19 anos do município de Caracol. Investigaram-se características demográficas, socioeconômicas, nutricionais, comportamentais e comorbidades. O desfecho foi a ocorrência de dor lombar (DL) nos últimos 12 meses. Foi calculada a prevalência do desfecho de acordo com as variáveis independentes. Entre os adolescentes com DL no último ano, foi calculada a proporção de indivíduos com dor lombar crônica. Para análise dos fatores associados, foi utilizada a regressão de Poisson bruta e ajustada para cálculo das razões de prevalência. A prevalência de dor lombar nos últimos 12 meses foi de 32,9%. De acordo com a análise ajustada, sexo feminino (RP = 1,75; IC95%:1,45-2,10), idade entre 18-19 anos (RP = 1,27; IC95%:1,01-1,62), maior renda (RP = 1,33; IC95%:1,06-1,67), estar trabalhando (RP 1,25 IC95%:1,02-1,53) e apresentar distúrbios psiquiátricos menores (RP 1,51 IC95%: 1,25-1,82) permaneceram associados à DL nos últimos 12 meses. Este estudo encontrou elevada prevalência de DL entre adolescentes de um município pequeno do semiárido nordestino.

Abstract The scope of this article is to assess low back pain prevalence and associated factors in the last 12 months among adolescents in a city in the south of the State of Piauí. It was a cross-sectional study which included 1,112 adolescents aged 13-19 in the city of Caracol, Piauí. Demographic, socio-economic, nutritional, behavioral and comorbidty characteristics were investigated. The outcome was the occurrence of low back pain (LBP) in the last 12 months. The outcome prevalence was calculated in accordance with independent variables. The proportion of individuals with chronic LBP was calculated among adolescents with LBP in the last 12 months. Crude and adjusted Poisson regression was used to estimate the prevalence ratio in the analysis of associated factors. The prevalence of LBP in the last 12 months was 32.9%. According to the adjusted analysis, being female (PR = 1.75; 95%CI:1.45-2.10), being aged 18-19 (PR = 1.27; 95%CI:1.01-1.62), having higher income (PR = 1.33; 95%CI:1.06-1.67), having a job (PR 1.25 95%CI:1.02-1.53) and having minor psychiatric disorders (PR 1.51 95%CI: 1.25-1.82) were associated with LBP in the last 12 months. This study found a high prevalence of LBP among adolescents in a poor city in the semiarid region of Northeast Brazil.